Assessing the Diagnostic Significance of Herpes Virus Infections’ Serological Markers in Children: Overdiagnosis or Clinically Relevant Studies? Retrospective Study

Background . Nowadays, population generally has high contamination with herpes virus infections. Infection commonly is asymptomatic, and the persists in human body over a lifetime. Excessive diagnosis of infections as well overestimation their role genesis various diseases immunocompetent people are common Russian pediatrics. Objective The aim study to assess frequency efficacy serological testing suspected correlation infectious somatic multidisciplinary hospital. Methods included patients hospitalized hospital Moscow, who were assigned examination for viruses. laboratory was carried out by enzyme-linked immunosorbent assay revealing markers simplex type 1 2, Epstein-Barr virus, cytomegalovirus. results analyzed according nosology management. Results identification infections’ performed 996 undergoing medical treatment 17 different departments within 2 months. Most prescribed disease, pediatric, hematological covered more than 140 nosologies. Acute respiratory infection, reactive arthritis, thrombocytopenia, mononucleosis, acute tonsillitis, gastrointestinal pathology, bronchitis, pneumonia most Positive infection revealed 1.71% cases HSV-1/HSV-2, 4.89% — EBV, 3.81% CMV. Moreover, positive mostly noted diseases: or Tests all three at same time cases. Conclusion Widespread typical variant overdiagnosis it usually less informative. Generally observed course when clinical picture enough verification.